Podcasts - For your listening pleasure

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Dr_SLO

Dr_SLO

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TWiV 606: Evidence-based science and medicine for COVID-19

In TWiV 606 Daniel Griffin provides his weekly update on the COVID-19 clinical situation and emphasizes the importance of evidence-based science and medicine. The TWiV team discuss tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.

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Dr_SLO

Dr_SLO

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TWiEVO 54: Rough drafts of SARS-CoV-2 science

In TWiEVO 54 Nels and Vincent are back and continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology.

This episode also highlights the limitation of using data from manuscripts submitted to bioRxiv and medRxiv before undergoing peer review.

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Dr_SLO

Dr_SLO

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TWiV 607: Coronavirus epidemiology with Jeff Shaman

Jeff Shaman, Professor of Environmental Health Sciences (in the International Research Institute for Climate and Society/Earth Institute) and Director, Climate and Health Program at Columbia, Mailman School of Public Health returns in TWiV 607. He explains why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

There has been a lot of recent discussion centered around epidemiology of SARS-CoV-2 and there's a lot of very useful information provided by Jeff that answers a lot of those points.

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Dr_SLO

Dr_SLO

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TWiV 608: Daniel Griffin’s COVID-19 clinical report

Daniel Griffin provides his weekly update in TWiV 608 and talks about the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

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Dr_SLO

Dr_SLO

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TWiV 609: A coronavirus chronology with Susan Weiss

Another dedicated coronavirologist, Susan Weiss, recalls some of her 40 years of research on coronaviruses in TWiV 609 and discusses mouse hepatitis virus, MERS-CoV, and SARS-CoV-2. That's right Susan has been studying these viruses for 40 years! More great information about what these little packages of protein and RNA can do.

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Dr_SLO

Dr_SLO

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TWiV 610: Coronavirus FAQ

In episode 610 the TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

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Dr_SLO

Dr_SLO

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TWiV 611: Corona and crowns

Daniel Griffin returns in TWiV 611 to provide a weekly clinical update on COVID-19 and discusses the new Kawasaki-like disease in children. Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

A quick note; this episode is long and a good portion of that is due to Michael Schmidt discussing SARS-CoV-2 and dentistry. Might be worth listening to that section at 2x speed.

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Dr_SLO

Dr_SLO

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TWiEVO 55: Coronavirus evolution from soup to nuts

There have been numerous reports in the media of late that new SARS-CoV-2 strains are emerging and are associated to either more severe disease or increased transmission. In TWiEVO 55, Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission. The critique of the second paper is a great listen as it gives a nice breakdown of how to recognize over interpretation of scientific data.

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Dr_SLO

Dr_SLO

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TWiV 612: CEPI, preventing the next pandemic

Episode 612 of TWiV was recorded in November 2019, pre-SARS-CoV-2, from the Nipah Virus International Conference in Singapore. Vincent spoke with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases partly in response to the 2014-16 ebolavirus outbreak in West Africa. This is a short episode of just 36 minutes and definitely worth a listen to understand that scientists have long recognized the potential for pandemic viruses and that an appropriate vaccine response strategy was needed.
 
Dr_SLO

Dr_SLO

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TWiV 613: Jenner, vaccines, and COVID-19

In TWiV 613, Vincent, Kathy and Rich explain the Jenner Institute’s SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Once again lots of interesting snippets from the TWiV team.

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Dr_SLO

Dr_SLO

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TWiV 614: COVID Tetris – Test, trace, isolate

Make sure you're sitting comfortably because TWiV 614 is a little longer than usual. If you listen to nothing else be sure to catch Daniel Griffin's clinical update on COVID-19 at the start of the show. The team then review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.

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Dr_SLO

Dr_SLO

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Immune 31: Immunology of COVID-19, part three

Immune 31 continues the discussion on the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

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Dr_SLO

Dr_SLO

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TWiV 615: Peter Daszak of EcoHealth Alliance

Another recorded episode (TWiV 615) from the Nipah Virus International Conference in Singapore, November 2019. Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. This is another excellent piece of insight about why surveillance programs for infectious diseases in wildlife are critical to prevent pandemics.
 
Dr_SLO

Dr_SLO

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TWiV 616: Singing about coronavirus

In TWiV 616 Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna’s mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

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Dr_SLO

Dr_SLO

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TWiEVO 56: Revising the drafts of coronavirus evolution

TWiEVO is fast becoming one of my favourite microbe.tv podcasts. Thinking about viruses from an evolutionary perspective really helps to solidify how they exist in populations. In TWiEVO 56 Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.

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Dr_SLO

Dr_SLO

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TWiV 617: Coronavirus Times

In TWiV 617 Daniel Griffin provides a clinical update on COVID-19, which has started to sound a lot more positive than in recent weeks. The TWiV team then review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

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Dr_SLO

Dr_SLO

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TWiV 618: Nipah virus at 20

TWiV 618 provides some respite from coronavirus to talk about another zoonosis from bats. From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.
 
Dr_SLO

Dr_SLO

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TWiV 619: Recombination led to emergence of SARS-CoV-2

Raul Rabadan returns to TWiV in episode 619 to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

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Dr_SLO

Dr_SLO

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TWiV 620: Antibodies and T cells in COVID-19 patients

Jon Yewdell returns in TWiV 620 to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. This episode really explores, in depth, the immunology that's starting to emerge surrounding SARS-CoV-2.

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Dr_SLO

Dr_SLO

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TWiV 621: An era of COVID-19 poppycock

In TWiV 621 Daniel Griffin provides his weekly clinical update on COVID-19; the good, the bad and the ugly. The TWiV team then review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

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