say your bike is kitted-out with every piece of data acquisition possible - suspension position, tire temp, IMU, strain gauges, etc. say you also pay a ridiculous amount of $$ to hire the best engineers in the world and to use the best pieces of software. do now have enough data, knowledge, and capabilities to fix or optimize every possible riding issue without guess and check? nope.
the problem is still indeterminate. you'll be able to optimize the majority of riding situations, but not all. you could probably input your bike, riding style, and track into a simulator and get a pretty damn good solution. but it won't be perfect.
how do I know? cuz MotoGP cant get it perfect. they show up to known track with a known bike on known tires with a known rider and still screw things up. sometimes they miss the setup so bad they go slower than previous years or previous tests.