info on the build stuff that's being done can be found at
www.450triple.com
On killing one of 4 cyls, there was imbalance concerns if a person opted to remove the piston/ rod, but not so much if they are left in, which all of us are doing.
Nobody that I know of has tried to convert to a twin, The detrimental effects of which, as far as imbalance goes, may be subject to displacement (ie: gsxr 1k --> 500 twin).
As Marcus mentioned, on the triumph triple, the loss was huge dropping one cylinder compared to dropping one in a 4 cyl engine