Anthony Fauci reports 'quite good news' from Remdesivir trial with control group

Climber

Well-known member
Seems like this drug deserves a thread of it's own, it's one of the few apparent bright spots.

Anthony Fauci reports 'quite good news' from Remdesivir trial with control group
Top White House health advisor Dr. Anthony Fauci reported that results from a trial of Remdesivir, an anti-viral drug developed by the Bay Area's Gilead Sciences that could help treat coronavirus patients, yielded "quite good news."

According to White House pool report, Fauci told reporters Wednesday that a National Institute of Allergy and Infectious Diseases trial of the drug that used a control group found a “clear cut positive effect in diminishing time to recover.”

A previous trial from the University of Chicago also had encouraging results, but there was no control group in that trial.

Fauci stated that researchers were primarily looking to evaluate if the drug increased rate of recovery, and found that patients who received the drug recovered in 11 days, and patients that did not receive the drug recovered in 15 days. That 31 percent improvement was deemed "very important" by Fauci.

In addition, the group that received Remdesivir saw a mortality rate of eight percent, compared to a mortality rate of 11 percent in the control group. Fauci stated the difference was not statistically significant, but was still encouraged by the rate of recovery numbers.

According to Fauci, the trial of over 1,000 people was the “first truly high-powered randomized placebo-controlled trial," and shows “a drug can block this virus."
 

Archimedes

Fire Watcher
Positive news for sure, but not the breakthrough every one was hoping for or that it is being touted to be. Most people don't understand that the threshold for proving 'efficacy' of a therapeutic is pretty low; it basically just has to afford some benefit, however small, over the options currently available, without killing the patient.
 

Blankpage

alien
I held Gilead stock for years on the hype over its hepatitis C drug and watched the stock do nothing for years. Good to see there's another tool to use against this virus but I'm not getting excited for the stock.
 

Heywood

Well-known member
What if you mix a little Remdesivir with some hydroxychloroquine followed by a z-pak chaser? :wtf
 

rodr

Well-known member
Fauci is director of the NIAID which is the agency that conducted this study. Would be good to see some independent verification.
 

Dr_SLO

Well-known member
Fauci is director of the NIAID which is the agency that conducted this study. Would be good to see some independent verification.

The Adaptive COVID-19 Treatment Trial (ACTT) NIAID study is the best study design to date. Previous studies indicating that remdesivir might have a benefit lacked placebo control groups. The NIAID study is a multi center, double-blind, placebo-controlled trial. The details of this ACTT study are provided by the NIH clinicaltrials.gov website, which is a great public access resource and tracks clinical trials from around the world.

Are more studies needed? Yes, but there is a reason that Fauci is encouraged by this trial. It's multi center, blinded and placebo controlled. These are the study parameters where most promising drugs fail.
 

Climber

Well-known member
Fauci is director of the NIAID which is the agency that conducted this study. Would be good to see some independent verification.
Dr Fauci has shown to have integrity, even when that integrity clearly put his professional career in his position at risk.
 

clutchslip

Not as fast as I look.
Dunno. It seems a bit over hyped, considering the best that is expected is reducing time in a ventilator for 4 or 5 days. That seems to indicate that you will either die or survive regardless of whether you get this drug.
 

Dr_SLO

Well-known member
Dunno. It seems a bit over hyped, considering the best that is expected is reducing time in a ventilator for 4 or 5 days. That seems to indicate that you will either die or survive regardless of whether you get this drug.

Agreed that it's most definitely not a magic bullet. However, if you can get patients off vents earlier, it provides quicker turnaround for patients in ICU freeing up resources more readily, enabling overrun hospitals more breathing space. We're not going to see a miracle drug emerge during this outbreak. A solid vaccine will be the most likely pharmaceutical intervention to clear this mess up.
 

Climber

Well-known member
Agreed that it's most definitely not a magic bullet. However, if you can get patients off vents earlier, it provides quicker turnaround for patients in ICU freeing up resources more readily, enabling overrun hospitals more breathing space. We're not going to see a miracle drug emerge during this outbreak. A solid vaccine will be the most likely pharmaceutical intervention to clear this mess up.
On that point, it has been touted that we have an abundance of ventilator's, so we're ready for anything.....what we don't have is an abundance of people to operate those ventilator's.
 

Climber

Well-known member
Don't records show most people don't survive the ventilators
One country (Italy?) only had around a 10% survival rate, I think in this country it's been a 30-50% survival rate. Less than 50% sucks, especially when there are issues after they recover, but it's better than 100% death rate if they aren't put on a ventilator at all.
 

Archimedes

Fire Watcher
Sounds like the pronation technique is likely just as, if not more, useful as this drug is in treating serious cases.
 

Dr_SLO

Well-known member
Sounds like the pronation technique is likely just as, if not more, useful as this drug is in treating serious cases.

Indeed, pronation has been a major contributor to better outcomes when treating serious disease. Remdesivir could be beneficial in stopping folk from falling into the severe disease category. It's going to be small increments like these that will provide the basis for reducing the clinical load.
 
Top