I gave the training on the new Hyper this year. It is completely different. The ergonomics are substantially changed. The 821 is a whole new motor - the Crank isn't even shimmed the way the other Ducati motors are. The SP has the trick suspension, but folks like me have to tippy toe to ride it. It has 185mm of Front wheel travel, compared to the base model with 170mm. The horsepower went up to 110, but the torque is lower than on the old 1100 so if it was the wheelie-monster you were after... this is a lot more tame -- which in most cases is a good thing.
The Multistrada is also revamped from the Main Bearings out. It has Secondary Air which has tremendously increased its low end driveability. The "S" models have the Skyhook suspension which takes time to get used to. Once you understand it and use it for a while... its awesome. The drawback is the getting used to it.
The Hyper is water-cooled, uses the 11 degree Testastretta design and blew the service intervals out to 9 & 18,000 miles!!! It's worth a look.